Liposomes have been utilised for quite some time now as an effective method for delivering drugs, nutrients, or genetic material into the body. With the vast therapeutic potential of CBD for many health conditions, companies are now looking into more advanced cannabis products to keep up with rising demand and new technological innovations. Liposomes for optimising active absorption of CBD are showing huge promise.

WHAT ARE LIPOSOMES?

Liposomes are tiny spheres of liquid made up of one or more phospholipid bilayers. They are usually created in a lab by disrupting phospholipids so that they form small protective bubbles. What makes liposomes unique and effective carriers is that they can safely transport ingredients through the gastrointestinal tract into target areas of the body.

Phospholipids contain a hydrophilic head that attracts water, and a hydrophobic tail that repels it. When they come into contact with water, the tails turn inward and the heads turn outward, which forms a bilayer. The result is a tiny liposome bubble that safely encapsulates ingredients and protects them against degradation.

Phospholipid Structure

WHAT ARE THE ADVANTAGES OF LIPOSOMES FOR DRUG DELIVERY?

Unlike other drug delivery methods, liposomes transport ingredients past the intestinal membrane to specific tissues. The ingredients inside these tiny spheres are fully protected as they reach the target areas in the body. The bioavailability of nutrients delivered via liposomes is therefore particularly high. After being exploited successfully by the traditional pharmaceuticals arena, liposomes are now being championed by the nutraceutical and CBD industries.

Liposomes are very safe since they are non-toxic and non-immunogenic. They are also highly biodegradable, unlike other carriers sometimes employed for drug delivery. There are no side effects to liposomes or their consumption in drugs or supplements.

LIPOSOMES AND CBD: A WINNING COMBINATION

CBD is particularly well-suited for delivery via liposomes. The reason for this is that CBD is non-psychoactive—so ingesting it in its unadulterated form doesn’t have any adverse effects. In fact, liposomes allow individuals to receive the optimal amount of CBD with each dose.

CBD delivered via liposomes is possible with both oral and topical formulations. Both of these intake methods are already popular. When used for oral consumption, liposomes allow for more accurate dosing. As the CBD is safely encapsulated and doesn’t get compromised on its way to target tissues, liposomes greatly improve CBD absorption. When employed in topicals such as creams and ointments, liposomes allow the CBD to penetrate deeper into the skin for a more pronounced effect.

Liposome and Cells

SCIENTIFIC STUDIES ON HOW LIPOSOMES INCREASE ABSORPTION

Scientific studies have found that delivery via liposomes improves the bioavailability of nutrients by protecting the drug in the gastrointestinal tract and mucous membranes. They also confirm their safety. A study published in 2017 states that “controllable release, which means that the loaded drugs are liberated in the right place and time, can significantly reduce administration times and avoid toxicity to other organs”.

The researchers assert that the unique form of liposomes allows them to “adhere to biomembranes, form mixed-micelle structures with bile salts to increase the solubility of poorly soluble drugs...”. This means that liposomes are well-suited for a variety of nutrients and substances that are not water-soluble.

An earlier study from 2003 looked at transdermal CBD delivery in particular. Researchers technically used ethosomes, which are delivery carriers similar to liposomes that enable drugs to reach deep into the skin’s layers. For this study, a group of mice were administered CBD to determine its efficacy in treating rheumatic diseases.

The researchers noted a significant accumulation of CBD in the skin and muscle, as well as a significant reduction in inflammation. They concluded that CBD, when delivered via small protective capsules such as ethosomes or liposomes, makes for an effective anti-inflammatory treatment. The results of these studies suggest that these delivery methods endow CBD with higher penetrative potential when compared to traditional delivery methods.

Liposomes For CBD Delivery

A PROMISING OUTLOOK FOR LIPOSOMES AND CBD

Using liposomes for the delivery of CBD is likely to result in numerous benefits for the consumer. Aside from delivering higher concentrations of CBD in general, liposomes allow individuals to use less CBD to achieve the same effect as other intake methods. Given these physiological and economic benefits, the future of liposomes and CBD looks to be nothing but bright.

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