We all know how cannabis is much safer than most pharmaceutical and recreational drugs out there. But being “safer” isn’t the same as 100% safe. This is a plant that contains over 100 active chemical compounds. While these might react safely with each other, it does not mean they’ll do the same with other drugs.

CBD is a very reliable medicine on its own. But there is still a lack of information regarding this compound. We still don’t know how it may react with all other substances we consume. We already know alcohol reacts poorly and possibly deadly with antibiotics. We need to be sure CBD doesn’t react this way with anything else before recommending it as a medicine.


Our metabolism is responsible for how fast we process substances in our system. Cytochrome P450 is an enzyme in the liver that helps metabolise CBD and over 60% of all pharmaceuticals. What’s possibly dangerous about CBD is that it takes full control of this enzyme and requires all of its attention.

When we intake CBD, the liver stops metabolising other drugs which use the same enzyme. If you’re taking a powerful painkiller like oxycodone, using CBD at the same time may cause it to stay in your system for longer than it should. These drugs were very carefully dosed to stay in your system for a specific period of time. Anything more than that, and you risk suffering from side effects like drowsiness and nausea. With regular use, liver damage can be a very serious consequence of this slow metabolic process.

Cytochrome P450 Enzyme


Any drug that is metabolised by the liver will be affected by CBD. These will be processed differently with the presence of this cannabinoid in the system. This means that anything from steroids to antibiotics or antidepressants will be affected. But the list goes on. Be sure you ask your doctor about this. Your dosage will most likely have to be reduced once you start medicating with CBD.

Even though a lot of medical professionals aren’t up-to-date when it comes to CBD and other cannabinoids, they’ll still be the most viable option when it comes to talking about your health. Even not knowing anything about CBD, they can still monitor your blood work to make sure you’re healthy. Being 100% honest with your doctor will only do you good. There is no reason to feel scared or ashamed of your belief in the healing powers of cannabis.

As far as you’re concerned, the use of CBD may actually help with your current medication. It won’t make its effects stronger; but by delaying the metabolic process, it can actually help you decrease your current dosage. Let’s take a look at a practical example.


In 2015, a study[1] analysed how CBD reacted with clobazam a famous anti-seizure drug on a group of epileptic children. CBD made for a slower metabolisation of this drug. Because of that, the patients were able to decrease the dosage of clobazam. This is a pharmaceutical with side effects like drowsiness, mild fever, loss of coordination, insomnia, and vomiting and constipation, just to name a few.

With such a long list of possible side effects, it’s extremely good news that one can reduce the quantity consumed with the help of CBD. This decrease in the amount of clobazam consumed is directly correlated with the diminished chance of experiencing side effects from the drug.


We’ve discussed how CBD can affect the behaviour of other drugs. But it is very important to note that when you smoke a joint, you’re likely not ingesting anywhere near the medicinal dose of CBD.

Most cannabis strains out there contain less than 1% CBD. With 1% CBD in each gram of weed, you’ll be consuming 10mg of CBD for every gram of bud. This is a very small quantity. Especially when considering epilepsy patients took up to 300mg of CBD to abate symptoms. This is the same as smoking 30 grams of bud (something we can all agree is a Snoop Dogg type of tolerance).

So, if you’re taking medication and use cannabis recreationally, just don’t abuse it. Pay close attention to what your body tells you. You shouldn’t feel any difference in the impact your medication has. But either way, ask your doctor for all the information he/she can give you. If you’re still worried, visit the doctor every month or so. This will help you be sure you’re fine and give you peace of mind.

Medical DisclaimerInformation listed, referenced or linked to on this website is for general educational purposes only and does not provide professional medical or legal advice.

Royal Queen Seeds does not condone, advocate or promote licit or illicit drug use. Royal Queen Seeds Cannot be held responsible for material from references on our pages or on pages to which we provide links, which condone, advocate or promote licit or illicit drug use or illegal activities. Please consult your Doctor/Health care Practitioner before using any products/methods listed, referenced or linked to on this website.

External Resources:
  1. Human Metabolites of Cannabidiol: A Review on Their Formation, Biological Activity, and Relevance in Therapy https://www.ncbi.nlm.nih.gov
This content is for educational purposes only. The information provided is derived from research gathered from external sources.

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